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   The Protective Effect of Sambucus Ebulus Against Lung Toxicity Induced By Gamma Irradiation in Mice  
   
نویسنده Karami Mohammad ,Ale-Nabi Sajad ,Nosrati Anahita ,Naimifar Atefeh
منبع Pharmaceutical And Biomedical Research - 2015 - دوره : 1 - شماره : 1 - صفحه:48 -54
چکیده    The aim of present study was to investigate the potential antioxidant and lung protective activities of sambucus ebulus (se) against toxicity induced by gamma irradiation. hydro alcoholic extract of se (20, 50 and 100 mg/kg ) was studied for its lung protective activity. . phenol and flavonoid contents of se were determined. male c57 mice were divided into 10 groups with five mice per group. only the first and second groups (as negative control) received intraperitoneally normal saline fluid. groups 3 to 5 received only se extract at doses of 20 mg/kg, 50 mg/kg and 100 mg/kg intraperitoneally three groups were repeatedly injected for 15 days as chronic group. groups 6 to 8 received a singledose of gamma irradiation just 2 hours before irradiation as acute group. the ninth and tenth groups (as positive control) received only gamma rays. animal was exposed wholebody to 6 gy gamma radiation. after irradiation, tissue sections of lung parenchyma were examined by light microscope for any histopathologic changes. se at doses 50 and 100mg/kg improved markedly histopathological changes induced by gamma irradiation in lung. lung protective effect of se could be due to attention of lipid peroxidation. our study demonstrated that se as a natural product has a protective effect against lung toxicity induced by gamma irradiation in animal.
کلیدواژه Sambucus Ebulusi ,Gamma Irradiation ,Histopathology Changes ,Antioxidant ,Lung Protective
آدرس Mazandaran University Of Medical Sciences, Faculty Of Pharmacy, Department Of Toxicology And Pharmacology, ایران, Mazandaran University Of Medical Sciences, Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, ایران, Mazandaran University Of Medical Sciences, Faculty Of Medicine, Department Of Pathology, ایران, Mazandaran University Of Medical Sciences, Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, ایران
 
     
   
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