evaluation of anti-psoriatic activity of aloe sinkatana extract on imiquimod induced psoriatic-like dermatitis in mice

Background: one of the most significant sudanese medicinal plants is aloe sinkatana, which has considerable pharmacological activity and has been historically used to treat psoriasis and other skin conditions. objectives: this study aims to evaluate the a. sinkatana plant’s anti-psoriatic properties. methods: the imiquimod (imq)-induced psoriasis mice model was used to evaluate the anti-psoriatic effect of the a. sinkatana plant. so, the effects of 0.1% and 0.2% extracts of a. sinkatana extract on five groups of mice were assessed and compared with the conventional medication, i.e. dexamethasone. differences between treatment groups were evaluated by a one-way analysis of variance, followed by a post hoc fisher least significant difference test using the spss software, version 20. at p<0.05, differences were deemed significant. a minimum of three replicates were used in each duplicate experiment. for all values, mean±sd was used. results: the extracts showed a significant and remarkably strong anti-psoriatic effect since the percentages of psoriasis-like symptoms were reduced in groups treated with 0.2% aloe extract (a.e), 0.1% a.e, and dexamethasone 86%, 84%, and 68%, respectively. both extract concentrations improved the psoriatic lesions and decreased the grading of the treated groups’ psoriasis area and severity index (pasi) scale.conclusion: due to the constant research to develop a safe and effective topical preparation for the treatment of psoriasis, the current study provided an enhanced anti-psoriatic treatment, represented by a. sinkatana extract. this herb may be beneficial in the pharmaceutical formulation of new safe and effective medication for treating psoriasis.