investigating clozapine-induced sialorrhea improvement in highland climate area: a case study

Background: this case report describes the elimination of clozapine-induced sialorrhea through a change in residence, highlighting how environmental factors can influence medication side effects. case report: the subject was a 39-year-old woman diagnosed with schizophrenia, who had been experiencing significant sialorrhea as a side effect of clozapine treatment. after relocating to a highland climate, the patient’s excessive salivation was significantly resolved. importantly, this change occurred without the need for any adjunctive medications, such as atropine, which are commonly prescribed to manage this side effect.conclusion: this case underscores the importance of considering environmental factors when evaluating drug effects in patients. it serves as a reminder to healthcare providers to be aware of how changes in a patient’s residence may impact the pharmacodynamics of medications, such as clozapine. understanding these dynamics can lead to more personalized treatment approaches and improved patient outcomes, emphasizing the need for further investigation into the relationship between climate and medication side effects.