comparing hydroxypropyl methylcellulose and guar gum on sustained release effect of metformin hydrochloride matrix tablet

Background and objectives: limited diabetes drug availability and frequent adverse reactions to oral medications highlight the need for improved drug delivery. this study suggests optimizing drug efficiency through process modifications, focusing on anti-diabetic medications like metformin hydrochloride. matrix-type formulations are utilized to overcome current drug targeting and dosage management limitations.methods: this study aims to improve anti-diabetic drugs, focusing on metformin hydrochloride, via process modifications in drug delivery. we developed a sustainable drug release process with matrix-type formulations, comparing hydroxyl propyl methylcellulose (hpmc) and guar gum as rate-controlling polymers. the optimized formulation was then compared with glyciphage sr 500 to identify similarities and differences in drug release profiles.results: we utilized matrix-type formulations to administer metformin hydrochloride. it develops a sustainable drug release process with hpmc and guar gum as rate-controlling polymers. next, we conducted comparative drug release studies, systematically optimized the formulation, and compared it to glyciphage sr 500 using appropriate analytical methods.results: comparative dissolution data, including a high similarity factor (f2) of 75.33 with glyciphage sr 500, emphasizes the promising resemblance between metformin hydrochloride tablet (mt5) and the market sample, warranting further stability studies for potential upscaling.conclusion: the study’s novelty lies in successfully formulating sustained-release mt5 using hpmc k100m and guar gum via wet granulation, demonstrating a potential reduction in dosing frequency and adverse effects. mt5’s optimal physical and chemical parameters and sustained drug release exceeded 99% at 12 hours.