effect of topical petroleum ether and ethyl acetate fractions from euphorbia milii on imiquimod-induced psoriasis-like skin inflammation in mice

Background: psoriasis is a chronic, untreatable and disabling disease. in this research, we investigated the pharmacological properties of euphorbia milii petroleum ether and ethyl acetate in a psoriasis mouse model. methods: thirty-one albino mice were used in this study. they were divided into five groups: group i, healthy animals; group ii, inducer group with imiquimod 12.5 mg (5% cream); and groups iii, iv and v were imiquimod-induced and then treated with clobetasol 0.05% in group iii, e. milii petroleum ether fraction in group iv and e. milii ethyl acetate fraction in group v. immunohistochemistry for interleukin-17 (il-17), vascular endothelial growth factor and transforming growth factor-beta, as well as histopathology were done on the mice skin.results: e. milii petroleum ether group showed a significant decrease in skin immunohistochemistry of il-17, transforming growth factor-beta, and other histopathology parameters, while ethyl acetate fraction showed a significant reduction in vascular endothelial growth factor and other histopathology parametersconclusion: e. milii petroleum ether and ethyl acetate fractions may have a role in psoriasis treatment in a mice model.