efficacy of omega-3, -6, and -9 fatty acids, alone or in combination with low dose aspirin, in improvement of uterine blood flow in women with history of recurrent miscarriage: a prospective, randomized, clinical trial

Background: much evidence suggests that increased uterine blood flow resistance (reduced uterine perfusion) raises the risk of recurrent miscarriage (rm).objectives: this study aimed at evaluating the efficacy of omega-3, -6, and -9 fatty acids,alone or in combination with aspirin, in reducing uterine blood flow resistance in women witha history of rm.methods: a total of 45 women with a history of two or more miscarriages and increased uterineartery blood flow resistance were included in this randomized clinical trial. they were randomlyassigned to aspirin (80 mg/d) (group a, n=15), omega-3, -6, and -9 fatty acids (4800 mg/d)(group o, n=15), or combination therapy (group ao, n=15). the patients were visited after twomonths, and the uterine artery blood flow resistance was measured by doppler sonography.results: the mean±sd age of participants was 32±3.5 years in group a, 32±3 years in group o,and 32.4±3 years in group ao. there was no significant difference between three groups in age(p=0.7), duration of marriage (p=0.55), duration of infertility (p=0.43) and number of previousmiscarriages (p= 0.51). in all three groups, after two months of treatment, the average uterineartery blood flow resistance reduced considerably compared with the beginning of the trial(p=0.0001); however, there was no significant difference between the three groups (p=0.56).conclusion: according to the study results, omega-3, -6, and -9 fatty acids can reduce uterineartery blood flow resistance and improve the uterine blood flow in women with rm, withequal efficacy to aspirin. also, combination therapy offers no advantages over monotherapy.