the effect of resistance training on malondialdehyde and protein carbonyl concentration in the heart tissue of rats exposed to stanozolol

Background: consumption of anabolic steroids causes damage to various tissues, including the heart. objectives: this study aimed to investigate the effect of resistance training (rt) on malondialdehyde (mda) and protein carbonyl (pc) in the heart tissue of rats exposed to stanozolol (s). methods: in this experimental study, 18 rats with the mean age of 8 weeks and weight range of 150 to 200 g were selected and divided into three groups of 6 rats: 1. sham (normal saline consumption) (sh), 2. s, and 3. s+rt. for 8 weeks, the s and s+rt groups received 5 mg/ kg/d s, and the s+rt group performed 5 rt sessions per week. measurement of mda and pc in the heart tissue was performed with the enzyme-linked immunosorbent assay. results: stanozolol had a significant effect on increasing mad (p=0.001) and pc (p=0.03) in the heart tissue. however, rt led to a decrease in mda and pc in the heart tissue of rats exposed to s (p=0.001). conclusion: it appears that s consumption leads to an increase in mda and pc levels in the heart tissue, while rt can improve the elevated levels of mda and pc.