Bioequivalence Study of Two Formulations of Tramadol Capsules in Healthy Myanmar Volunteers

Background: tramadol is one of the most commonly used analgesics, thanks to its efficacy and safety. it is widely used in myanmar for postoperative and cancer pain control. the use of generic drugs has been steadily increasing worldwide, mostly in developing countries. generic drugs should have efficacy and safety comparable to their innovators or other approved generic products. objectives: this study aims to compare the bioequivalence of locally producing, tramadol bpi reg; capsule (test product) with the tramazac reg; capsule (reference product) in healthy myanmar volunteers.methods: the bioequivalence was determined in 16 healthy myanmar volunteers after a single oral administration of 100 mg tramadol (under fasting condition) in a randomized, openlabel, twoperiod, and twotreatment crossover study with a twoweek washout period. blood samples were collected at specified times, and plasma tramadol concentrations were measured with a validated highperformance liquid chromatography method with a fluorescence detector. pharmacokinetic parameters were determined using the plasma concentrationtime data in a noncompartmental model.results: the analysis of variance of the logarithmically transformed parameters (maximum plasma concentration (cmax), area under the concentrationtime curve from the time of administration to the last measured concentration (auc0t), and to infinity (auc0 infin;) revealed no sequence, period, and formulation effects between the test and reference products. significant differences were found between the subjects within the sequence for both auc0t, and auc0 infin;, indicating a substantial intersubject variation. the geometric mean ratio of test/reference and their 90% confidence intervals were within the asean (association of southeast asian nations) bioequivalence acceptance interval of 80% to 125%.conclusion: tramadol bpi reg; and tramazac reg; capsules, after a single oral administration of 100 mg, were bioequivalent in respect of their rate and extent of absorption under fasting condition.