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in vitro antitumor activity of patulin on cervical and colorectal cancer cell lines
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نویسنده
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abastabar m ,akbari a ,akhtari j ,hedayati mt ,shokohi t ,mehrad-majd h ,ghalehnoei h ,ghasemi s
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منبع
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current medical mycology - 2017 - دوره : 3 - شماره : 1 - صفحه:25 -29
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چکیده
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Background and purpose: patulin is a mycotoxin produced by some molds, especially aspergillus and penicilium, and is responsible for mycotoxicosis in animals and humans. there is still not very detailed data about the anti-cancer potency of patulin, but some reports demonstrated that it induces cellular apoptosis and toxicity. materials and methods: to determine the efficacy of patulin as a therapeutic strategy for cervical and colorectal cancers, we investigated its effects on hela, sw-48, and mrc-5 cell lines. cell lines were exposed to various concentrations of patulin (i.e., 0.5, 1, 2, and 4 μm), then using methyl thiazolyl tetrazolium (mtt) and bromo-2′-deoxyuridine (brdu) assays, the rates of apoptosis and cell viability were determined. results: the obtained results showed a significant reduction in cell viability and apoptosis induction in a dose-dependent manner. among all the cell lines, the highest growth inhibition rate was obtained at the 4 μm concentration of patulin. conclusion: our results suggested that patulin could significantly decrease tumor growth in human cervical and colorectal cancer models.
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کلیدواژه
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cancer ,hela cells ,mycotoxin ,patulin
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آدرس
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mazandaran university of medical sciences, invasive fungi research center (ifrc), department of medical mycology and parasitology, ایران, iran university of medical sciences, colorectal research center, ایران, mazandaran university of medical sciences, school of advanced technologies in medicine, immunogenetics research center, department of medical nanotechnology, ایران, mazandaran university of medical sciences, invasive fungi research center (ifrc), department of medical mycology and parasitology, ایران, mazandaran university of medical sciences, invasive fungi research center (ifrc), department of medical mycology and parasitology, ایران, mashhad university of medical sciences, clinical research unit, ایران, mazandaran university of medical sciences, immunogenetics research center, ایران, mazandaran university of medical sciences, school of medicine, department of parasitology and mycology, students research committee, ایران
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Authors
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