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in vitro activity of econazole in comparison with three common antifungal agents against clinical candida strains isolated from superficial infections
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نویسنده
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abastabar m ,shokohi t ,rouhi kord r ,badali h ,hashemi j ,ghasemi z ,ghojoghi a ,baghi n ,abdollahi m ,hosseinpoor s ,rahimi n ,seifi z ,gholami s ,haghani i ,jabari mr ,pagheh a
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منبع
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current medical mycology - 2015 - دوره : 1 - شماره : 4 - صفحه:7 -12
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چکیده
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Background and purpose: candida species are the most common organisms involved in superficial fungal infections, worldwide. although econazole is among the most frequently used topical formulations for the treatment of candidiasis, no information is available regarding the susceptibility profiles of candida species in iran. materials and methods: in vitro susceptibility of 100 clinical candida isolates belonging to 6 species from superficial candidiasis of iran towards to econazole was compared with three other common antifungal agents including itraconazole, fluconazole, and miconazole. minimum inhibitory concentrations (mics) values were analyzed according to the clinical and laboratory standards institute (clsi) m38-a3 document. all isolates were previously identified to the species level, using polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp) on its region. results: the mic of econazole, itraconazole, miconazole, and fluconazole were within the range of 0.016-16, 0.032-16, 0.016-16, and 0.25-64 μg/ml, respectively. in general, econazole and miconazole were more active against candida isolates, compared to the other two agents. conclusion: the present study demonstrated that for candida albicans isolates, miconazole and econazole had the best effect, but in nonalbicans candida species, itraconazole and miconazole displayed more activity than other antifungal agents.
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کلیدواژه
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antifungal susceptibility ,econazole ,superficial candidiasis
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آدرس
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mazandaran university of medical sciences, school of medicine, invasive fungi research center (ifrc), department of medical mycology and parasitology, ایران, mazandaran university of medical sciences, school of medicine, invasive fungi research center (ifrc), department of medical mycology and parasitology, ایران, mazandaran university of medical sciences, student research committee, ایران, mazandaran university of medical sciences, school of medicine, invasive fungi research center (ifrc), department of medical mycology and parasitology, ایران, tehran university of medical sciences tums, school of medicine, department of medical parasitology and mycology, ایران, tehran university of medical sciences tums, school of medicine, department of medical parasitology and mycology, ایران, mazandaran university of medical sciences, toxoplasmosis research center, ایران, mazandaran university of medical sciences, student research committee, ایران, mazandaran university of medical sciences, school of medicine, department of microbiology and immunology, student research committee, ایران, mazandaran university of medical sciences, student research committee, ایران, mazandaran university of medical sciences, student research committee, ایران, mazandaran university of medical sciences, student research committee, ایران, mazandaran university of medical sciences, school of medicine, invasive fungi research center (ifrc), department of medical mycology and parasitology, ایران, mazandaran university of medical sciences, school of medicine, invasive fungi research center (ifrc), department of medical mycology and parasitology, ایران, mazandaran university of medical sciences, student research committee, ایران, mazandaran university of medical sciences, toxoplasmosis research center, student research committee, ایران
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Authors
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