Dose and prognosis evaluation in colchicine intoxications [Kolşisin Zehirlenmelerinde doz ve Prognoz Deǧerlendirmesi]

Objective: we aimed to evaluate the relationship between dose and prognosis in patients admitted to icu with colchicine intoxication and to provide a viewpoint for systemic abnormalities due to dosage. cases: patients who were followed up between 2008-2015 in icu due to colchicine intoxication were evaluated retrospectively. totally 9 patient's charts were obtained from archives and their demographic data,laboratory and clinical findings during admission to emergency service and icu,hepatic and coagulation abnormalities and their rising time,treatment given,lenght of stay in hospital and mortality rates were recorded. ages were between 16-22 in 9 patients. one of the patients was male and 8 were female. in 1 out of 9 patients,exitus occured. it was found that 4 patients were using colchicine because of fmf (famial mediterranean fever) and behcet disease. the dose of exitus was 1.1 mg kg1. from the rest of the patients dose was 0.6 mg kg' in one of them and under 0.5 mg kg1 in others. eight patients showed coagulation abnormality. coagulation abnormalities were occured between the 6th and 36th hours four patients showed nausea and vomiting and 4 patients showed hepatic abnormality. hepatic abnormalities were occured between the 8th and 72nd hours. conclusion: we agree that it should be kept in mind by intensivists that in colchicine intoxications,nausea-vomiting,hepatic and coagulation abnormalities may be seen in small doses and different time periods and these patients should be followed up closely in icu.