Repetitive use of propofol in children undergoing radiation therapy [Radyoterapi alan çocuk hastalarda tekrarlayan propofol uygulamalari]

Objective: our aim was to investigate the alterations of propofol requirements in children undergoing long-term radiotherapy under anesthesia on consecutive days,to conceive the trend towards rise or fall,during repetitive use of propofol. method: the anesthesia records of children who received radiotherapy under deep sedation between march 2014-march 2015 were obtained. the primary outcome was the alteration in total induction dose of propofol needed for each session during treatment. the radiotherapy periods were divided into weeks and mean propofol doses for each week were used for comparisons. the mean dose of each week was also compared to the first day. results: 421 treatment sessions of 22 children were analyzed. the propofol doses altered by mean doses of 0.206 mg kg' (95% ci;-0.063-0.476) within the 1st,0.271 mg kg' (95% ci ;0.034-0.508) within the 2nd,0.368 mg kg' (95% ci; 0.013-0.723) within the 3rd and 0.657 mg kg' (95% ci; 0.232-1.082) within the 4th weeks of treatment periods compared to 1st day (p<0.05). the doses fluctuated revealing a difference of 1.16+0.83 mg kg' between minimum and maximum doses (95% ci; 0.80-1.53). 50% of patients had higher doses in 1st week,68.2% in 2nd,53.3% in 3rd and 78.6% in 4th week compared to 1st day. conclusion: the induction doses of propofol fluctuated during long-term repetitive use on consecutive days with a trend towards rise.