Comparison of preemptive administration of lornoxicam and tramadol on postoperative analgesia [Preempti̇f olarak kullanilan lornoksi̇kam ve tramadolün postoperati̇f analjezi̇ye katkilarinin karşilaştirilmasi]

Objective: the purpose of the study was to determine the efficacy of preoperative intravenous (iv) tramadol and two different doses of lornoxicam on postoperative analgesia. method: eighty asa i-ii patients undergoing total abdominal hysterectomy were enrolled in the study,and were randomized into four groups: group l1 received 8 mg of iv lornoxicam,group l2 received 16 mg of iv lornoxicam,group t received 100 mg of iv tramadol and group k received normal saline of the same volume before the surgery. all patients received standard general anaesthesia. in the recovery room,patient controlled iv morphine was initiated for postoperative analgesia after they were extubated. postoperative pain was assessed by measuring morphine consumption and visual analog pain scores (vas) at the extubation (0) and postoperative 6,12 and 24 hours. results: the time to first analgesic requirement (effective analgesia times) was approximately 2 ± 1 minute (min) in group l1,4 ± 3 min in group l2,4 ± 4 min in group t and 2 ± 1 min in group k. when compared to group l2 and group t,effective analgesia times were significantly higher in group k and group l1,which had similar values between themselves (p<0.05). vas scores after the extubation were significantly higher in group k and group l1 (p<0.05). vas scores at the 6 th hour were significantly different among group l1,group k and group t (p<0.05). there was no significant difference among the groups regarding total morphine consumption. conclusion: administration of iv 8 mg lornoxicam before the total abdominal hysterectomies for preempive analgesia was found to be insufficient,and no difference has been found between group l1 and group t with respect to effective analgesic period. however,there has been a comparable preemptive analgesic effect of iv 16 mg lornoxicam and tramadol 100 mg administration till the first 6 hours after the surgery.