Hypotensive anesthesia in tympanoplasty operation: Comparison of dexmedetomidine and magnesium sulphate [Ti̇mpanoplasti̇ operasyonlarinda hi̇potansi̇f anestezi̇: Deksmedetomi̇di̇n ve magnezyum sülfatin karşilaştirilmasi]

Objective: the aim of this study was to compare dexmedetomidine and magnesium sulphate regarding their efficiency in hypotensive anesthesia and operative field during tympanoplasty. method: after getting the approval of the ethics committee,40 patients,who were scheduled for tympanoplasty surgery,aged 18-65 years,asa i-ii,were included in randomized double-blinded study. in addition to the standard monitorization,bispectral index and muscle nerve monitorization were performed. before induction of anesthesia,magnesium group received an infusion of 30 mg kg-1 % 10 mgso4 as a loading dose in 10 minutes and 10 mg kg-1 hr-1 infusion was performed throughout the operation. dexmedetomidine group received an infusion of 1 μg kg-1 as a loading dose in 10 minutes before induction,followed by 0.5 mg kg-1 hr-1 infusion throughout the operation. the target mean arterial pressure was in the range of 60 to 65 mmhg. surgical field bleeding was evaluated by asking the surgeon. times to extubation,verbal response times,orientation times and postoperative sedation scores of the patients were recorded. results: there was no significiant difference between the groups in terms of demographic characteristics and duration of the operation. mean arterial pressure measurements except for the first 30 minutes and before extubation,and heart rate measurements except before induction were significantly lower in the dexmedetomidine group (p<0.05). surgical bleeding score was significiantly lower in the dexmedetomidine group in all measurement times. nitroglycerin and fentanyl requirements were significantly higher in the magnesium group. time to extubation,verbal response times,and orientation times were similar between two groups,however,sedation scores were significantly higher in the magnesium group (p<0.05). conclusion: we think that dexmedetomidine is a good option for controlled hypotensive anesthesia due to rapid onset,more stable intraoperative hemodynamics and provided better surgical field.