the role of interleukin (il-22) in immune response to human diseases

Background and aims: il-22 is an alpha- helical cytokine. il-22 binds to a heterodimeric cell surface receptor composed of il-10r2 and il-22r1subunits. il-22r is expressed on tissue cells, and it is absent on immune cells. l-22 and il-10 receptor chains play a role in cellular targeting and signal transduction to selectively initiate and regulate immune responses. the aim of this study was to investigate the role of interleukin (il-22) in immune response in human diseases. methods: this study was a mini-review research to investigate the role of t helper 22 (th22) in immune response. results: il-22 contributes to immune disease through the stimulation of inflammatory responses, s100s and defensins. il-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to il-10. in some contexts, the pro-inflammatory versus tissue-protective functions of il-22 are regulated by the often co-expressed cytokine il-17a. il-22 confirms regulation of antimicrobial proteins. targeting the il-22–il-22r pathway may yield new therapeutic potential for the treatment of certain human diseases. conclusion: il-22 is expressed constitutively by lti-like cells within the small intestine, a tissue that is under the careful immune balance between inflammation and tolerance. gaining a better understanding of the expression and role of il-22 in health and disease is important for development of il-22 as a potential drug target il-22 is expressed constitutively by lti-like cells within the small intestine, a tissue that is under the careful immune balance between inflammation and tolerance. obtaining a better understanding of the expression and role of il-22 in health and disease is important for development of il-22 as a potential drug target.