Epidemiologic and Clinical Characteristics of Guillain-Barré Syndrome in Patients Referred To Sina Hospital in Hamadan in 2018

Background and aims: guillain-barré syndrome (gbs) has several types, some of which damage myelin and some others cause axonal damage. detecting the type of gbs is important in determining the type of treatment and its prognosis. this study was conducted to investigate the epidemiological characteristics of gbs and its variants in patients referred to sina hospital in hamadan, iran, in 2018. methods: in this cross-sectional study, 51 patients who were admitted to sina hospital and diagnosed with gbs in 2018 were examined. demographic data, gbs type, disease outcomes, and pre-clinical and clinical findings of patients were collected. data were then analyzed using the stata software version 12, and p value < 0.05 was considered statistically significant. results: of the 51 investigated patients, 34 (66.66%) were male. the most common variant type was acute inflammatory demyelinating polyneuropathy (aidp) with 27.45% of cases followed by acute motor axonal neuropathy (aman) with 19.61% of cases. further, the highest average hospitalization days (11.1 ± 11.7 days) were for chronic inflammatory demyelinating polyneuropathy (cidp) patients, while the lowest (6.85 ± 1.91 days) was for aidp patients (p < 0.001). all cidp cases occurred in spring, and 71.43% of aidp cases occurred in summer. moreover, all 7 cases with acute motor and sensory axonal neuropathy (amsan) syndrome and the only case with the miller-fisher syndrome (mfs) occurred in fall (p < 0.001). conclusion: according to the results of this study, most variants of gbs in hamadan province were aidp in demyelinating form and aman variant in the axonal deterioration form. however, studies with a larger sample size are recommended in the west of iran to better understand the epidemiology and to ensure common types of gbs.