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Synthesis and Structural Properties of Polyvinylpyrrolidone Based Nanocomposite Hydrogels For Isoniazid Drug Delivery
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نویسنده
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Fathinrjadjirandehi Hassan ,Adimi Maryam ,Heydari Naqdali Mokhtar
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منبع
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Journal Of Particle Science And Technology - 2015 - دوره : 1 - شماره : 3 - صفحه:183 -193
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چکیده
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In this study, several exles of hydrogels and nanocomposite hydrogels based on pvp with different content of montmorillonite nanoclay were prepared. then, the swelling of hydrogels and kinetics of drug delivery of hydrogel in an environment similar to the body (ph 7.4) were examined. the effect of nanoparticle different percentages on the hydrogel was clearly observed. then kinetics of drug (isoniazid) delivery for various sles of hydrogel with nanoparticles and without nanoparticles were obtained via peppas and higuchi models. the comparison of peppas model results with experimental data showed that nanocomposite with 4% nanoclay exhibited better compliance. the morphology and microstructure of the prepared nanocomposites were studied by ftir, xrd and sem.
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کلیدواژه
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Hydrogel Nanocomposite ,Polyvinylpyrrolidone ,Swelling ,Controlled Release ,Isoniazid
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آدرس
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Islamic Azad University, Farahan Branch, Young Researchers And Elite Club, ایران, Islamic Azad University, Farahan Branch, Young Researchers And Elite Club, ایران, Islamic Azad University, Farahan Branch, Department Of Chemical Engineering, ایران
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پست الکترونیکی
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ali.heidari9357211895@gmail.com
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Authors
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