mir-148 and mir-375 expression in oral squamous cell carcinoma patients with oral infection in comparison with oscc patients without oral infection

Introduction: oral squamous cell carcinoma is a multifactorial disease that is the sixth most common cancer worldwide. micrornas have been confirmed to play a role in oral squamous cell carcinoma, acting as either oncogenes or tumor suppressor genes. this study examined the expression level and role of micror-148 and micror-375 in oral cancer. materials and methods: in this study, we used 30 cancer samples with infection and 30 cancer samples without infection. to analyze the expression of microrna 375 and microrna 148, we used real-time pcr. first, we extracted total rna from the samples. then, we generated cdna from it. finally, the obtained cdna was used in the real-time pcr technique. results: in cancer patients with oral infection, there was an increase in microrna-148 expression and a decrease in microrna-375 compared to cancer patients without oral infection. conclusion: the downregulation of microrna-375 and upregulation of microrna-148 can be utilized as diagnostic biomarkers and prognostic factors in oral cancer.