solitary intraosseous neurofibroma of mandible: a case report

Neurofibroma is a benign tumor derived from the peripheral nerve. most of these can be multifocal as a component of neurofibromatosis or present as a solitary tumor. although the solitary neurofibroma is not an uncommon lesion, its intraosseous occurrence is rare, and less than 50 cases have been reported. we report a rare case of central neurofibroma, arising in the mandibular bone of 57-year-old edentulous female patient on the left side. hemi mandibulectomy was performed and reconstructed with a reconstruction plate without any bone graft. microscopic evaluation showed neoplastic tissue with haphazardly arranged and interlacing fascicular patterns composed of point-ended spindle-shaped tumoral cells. immunohistochemical examination of the tumor showed positive staining for s-100 protein antibodies.