comparing salivary mir-125 and mir-30 expression in oral squamous cell carcinoma to healthy individuals

Introduction: oscc (oral squamous cell carcinoma) accounts for approximately 90% of all oral malignancies and is usually diagnosed at advanced stages. this study investigates changes in mir-125 and mir-30 expression in relation to the clinical findings of oral cavity cancer and their possible use as an early diagnostic tool. materials and methods: a population of 30 individuals with oral squamous cell carcinoma and 30 healthy individuals was studied, and the mean age of two groups were compared using a t-test, with no significant difference found in terms of age so age will not be an interfering factor in this study. the levels of these two biomarkers (mir-125 and mir-30) were measured and evaluated using real-time pcr technique. results: after evaluating the results of real-time pcr technique, it was found that mir-125 was positive in 25 out of 30 patients, while it was positive in 5 out of 30 healthy individuals (p-value≤ 0.001). mir-30 was a positive biomarker in 10 out of 30 patients. the amount of this biomarker in the group of healthy individuals was 26 out of 30 (p-value<0.001). conclusion: the mir-125 profile is upregulated in the saliva of oscc cases, whereas the mir- 30 profile is downregulated in the aforementioned patients compared with the healthy group. therefore, measurement of mir-125 and mir-30 may be a protentional diagnostic test to identify oscc. we suggest more extensive studies with a larger sample size to support this claim.