comparative efficacy of haloperidol and placebo for treatment of delirium induced by biperiden and lps in adult male rats based on their learning style and change in their short term spatial memory

Background and objectives: delirium refers to acute loss of consciousness and is characterizedby confused thinking and impaired orientation. it is a life-threatening, but reversiblesyndrome manifested by cognitive impairment, abnormal psychomotor activity and sleep disturbances.due to high prevalence in hospitalized patients and high rate of morbidity and mortality,delirium significantly decreases the prognosis of hospitalized patients.materials and methods: this experimental animal study evaluated 54 adult male wistarrats over 2 months of age that weighed 200 to 230g. of all, 24 rats received biperiden (40mg/kg)while the remaining 24 received 50μg/kg lps. induction of delirium was ensured using a y-mazeafter 3 hours. the control group included 6 rats the efficacy of different doses of haloperidol fortreatment of delirium was assessed 3 h after injection using the y-maze. data were compared usingone-way anova followed by tukey’s post-hoc test via graphpad prism.results: haloperidol at 0.1, 0.2 and 0.5mg/kg dosage significantly increased the percentage ofspontaneous alternation and improved the memory, consciousness and learning compared withbiperiden and lps groups (p<0.01). no significant difference was noted between the haloperidolgroups regarding efficacy (p>0.05).conclusion: delirium is characterized by attention deficit, impaired orientation, changes inmemory, consciousness, perception and mood, and psychotic symptoms. detection of the completespectrum of delirium signs and symptoms in an animal that cannot talk (rat) is obviouslydifficult. using of y-maze can facilitate this problem.