Trend of Antibiotic Resistance Among Acinetobacter spp. Strains Isolated From Wound Infections in Ghaem University Hospital in Northeast of Iran From 2005 to 2011

Acinetobacter has become an important cause of different infections such as wound infection, due to its great ability to survive and spread in hospital settings and to develop resistance against many antibiotics. the aim of this study was to investigate the antibiotic resistance among isolates of acinetobacter from wound infections during a 7-year period, from 2005 to 2011, in ghaem university hospital, mashhad. during this period, patients with nosocomial wound infections were identified according to national nosocomial infections surveillance system (nnis) and appropriate samples were taken from their wounds. furthermore, microbiological procedures were performed to identify the bacterial strains causing the infection. antibiotic susceptibility of acinetobacter isolates was determined by disk diffusion method. based on the guideline, 324 cases of infection were identified and 43 samples of acinetobacter strains were isolated. during this 7-year period, the resistance to kanamycin and norfloxacin was increased among these 43 samples. however, the resistance against ampicillin, ciprofloxacin, cefexime, trimethoprim-sulfamethoxazole, cefotaxime, cefazolin, gentamicin, and ceftizoxime was not significantly increased. the overall bacterial resistance was high. the pick of acinetobacter species was observed in 2006 and 2007. our results demonstrated a high antibiotic resistance among acinetobacter species isolated from wound infections. the increased resistance to antibiotics such as kanamycin and norfloxacin was due to their vast application in treatments. moreover, the decreased resistance to other noted antibiotics was probably due to their low application.