Evaluation of Efficacy and Potential Complications of the Plant-Based Nanoparticles Hemostat Powder on Controlling Hemorrhage in Rat Models of Liver Injury: An Experimental Study

Backgroundliver resection requires time management due to the high risk of bleeding. plant-based materials are superior to other agents inreducing complications during hemostasis. this present study aimed to investigate the effect of plant-based topical hemostaticnanoparticles from the rosaceous as an innovative hemostatic agent.materials and methodstwenty male wistar rats were randomly divided into two study groups. all rats were anesthetized and their anterior lobe of theliver was amputated. the incision site was directly pressed with a dry gauze for 2 minutes in the control group and repeated every30 seconds until hemostasis was achieved. homeostatic material was compressed on the incision site and clotting time wasrecorded in the intervention group. the mean hemostasis time was compared in both groups using paired samples test. p <0.05was considered statistically significant.resultshemostasis was successfully achieved in both groups. the hemostasis time were 6.7±1.33 and 183±26.26 in nanoparticles andcontrol groups, respectively and their differences were significant (p<0.001). histopathology evaluation indicated a slight increasein vascularity, fibrosis, and polymorphonuclear neutrophil (pmn) infiltration in one case. mild to moderate lymphocyteinfiltration was detected in 2 cases.conclusionthe produced plant-based nanoparticles could significantly reduce the hemostasis time in the intervention group compared to thatof the control one