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Effect of Amyloid β- Peptide on Passive Avoidance Learning in Rats: A Behavioral Study
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نویسنده
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Nikkhah Ali ,Ghahremanitamadon Fatemeh ,Zargooshnia Somayeh ,Shahidi Siamak ,Soleimani Asl Sara
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منبع
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avicenna journal of neuro psycho physiology - 2014 - دوره : 1 - شماره : 1 - صفحه:1 -4
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چکیده
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Alzheimer's disease (ad) is the most common form of dementia that leads to neurotoxicity. amyloid β-peptide (aβ) has a pivotal role in the pathogenesis of ad. given the contradictory results of aβ (25-35) on the memory, in the present study we have examined the effect of aβ - induced memory impairment. wistar male rats received an intrahippocampal (ihp) injection of aβ (25-35).the learning function in the rats was examined by the passive avoidance task. the results showed that aβ (25-35) significantly impaired both step-through latency and time in dark compartment in the passive avoidance task. these data suggest that single bilateral microinjection of aβ (25-35) could impair memory and can be used as an ad model in wistar rats.
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کلیدواژه
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Alzheimer's disease ,Amyloid β-peptide ,Learning ,Rats
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آدرس
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Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran, Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran, IR Iran, Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran, Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran, IR Iran, Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran, Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran, IR Iran, Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran, Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran, IR Iran, Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran, Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, IR Iran, IR Iran
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پست الکترونیکی
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s.soleimaniasl@umsha.ac.ir
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Authors
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