The relationship between Metabolic Syndrome and left Ventricular Mass index in Obese children

Objective: to investigate the relationships between metabolic syndrome (ms),other metabolic features and left ventricular mass index (lvmi) in a population of obese children and adolescents with ms. methods: two hundred and eight obese children and adolescents (119 females and 89 males,mean age: 11.9±2.7 years) and control subjects (24 females and 26 males,mean age: 11.4±2.9 years) were enrolled in the study. the insulin sensitivity index and lvmi were determined. the international diabetes federation criteria were used to diagnose ms. results: the obese patients were divided into ms group (n=55) and non-ms (n=153) group. the values of lvmi in the ms group were significantly higher than those in the non-ms group (p=0.014). the present lvmi cut-off point of 33g/m2 for the diagnosis of ms yielded a sensitivity of 97% and a specificity of 98%. lvmi was found to be positively correlated in univariate analysis with height,weight,body mass index (bmi) sds,fasting insulin level,homeostasis model assessment of insulin resistance (homa-ir) and fasting glucose to insulin ratio (fgir) and negatively correlated with quantitative insulin sensitivity check index (quick-i). conclusions: we suggest that our optimal lvmi cut-off value for identifying ms may be considered as a sensitive index in screening obese children and adolescents for pediatric ms. assessment of lvmi in obese children and adolescents may be used as a tool in predicting the presence of ms and its associated cardiovascular risks. © journal of clinical research in pediatric endocrinology.