Vanishing testes: A literature review

Vanishing testes syndrome is often referred to as testicular regression syndrome (trs) in the recent medical literature. the most characteristic histological findings are presence of a fibrovascular nodule with associated hemosiderin-laden macrophages and dystrophic calcification. residual testicular tubules are found in less than 10% of cases,with prevalence being unrelated to age at surgery. presence of seminiferous tubules and viable germ cells in testicular remnant tissue has been reported in some series. trs theoretically carries a potential for malignant degeneration in the long term and therefore removal of any remnant is a common practice to eliminate this risk. however,no case series has reported germinal dysplasia or intratubular germ cell neoplasia in any of the specimens taken from these patients. ©journal of clinical research in pediatric endocrinology,published by galenos publishing.