Trends in the frequency of HLA DR-DQ haplotypes among children and adolescents with type 1 diabetes mellitus in the Southeast Region of Turkey

Objective: the aim of this study was to determine the frequency of hla dr-dq haplotypes in children with type 1 diabetes mellitus (t1dm) in the southeast region of turkey. methods: eighty children and adolescents with t1dm and eighty control subjects participated in the study. hla-dr,dq was typed using polymerase chain reaction and sequence-specific priming technique. results: hla drb1*03 allele was significantly more common in patients than in control subjects. hla drb1*11,hla drb1*13 and hla drb1*14 allele frequencies were significantly lower in patients than in controls. dqb1*02 allele was more common in patients,whereas dqb1*03 allele was more frequent in control subjects. hla drb1*03-dqb1*02 haplotype was more frequently observed among patients. conclusion: these results confirm the similar potential trends in the frequency distribution of hla susceptibility genes with t1dm previously observed in turkey and in other caucasian populations.© journal of clinical research in pediatric endocrinology.