CTLA-4 (+49A/G) polymorphism and type-1diabetes in Turkish children

Objective: to evaluate the contribution of cytotoxic t-iymphocyte antigen-4 (ctla-4)+49a/g polymorphism to the susceptibility to type-1 diabetes (t1d) in turkish children. methods: a case-control study was designed to include 91 turkish children with t1d and 99 healthy controls. ctla-4 (+99a/g) gene polymorphism typing was done by pcr amplification followed by restriction fragment length polymorphism method. results: the genotype and allele frequencies of the ctla-4 (+99a/g) polymorphism in patients with t1d were not different from those in the controls (p>0.05). the allele frequency of g was 36.2% in patients with t1d,and 31.8% in controls (p>0.05). additionally,this polymorphism was not associated with the clinical and laboratory characteristics of the patients with t1d (p>0.05). conclusions: our case-control study suggests that the ctla-4 (+99a/g) gene polymorphism is not associated with t1d in the turkish population. © journal of clinical research in pediatric endocrinology,published by galenos publishing.