β-3AR W64R polymorphism and 30-minute post-challenge plasma glucose levels in obese children

Objective: in this study,we aimed to investigate the association of w64r polymorphism of the β3-adrenergic receptor gene (β-3ar) with childhood obesity and related pathologies. methods: β-3ar gene w64r genotyping was carried out in 251 children aged 6-18 years. of these subjects,130 were obese (62 boys) and 121 were normal-weight (53 boys). in the obese group,fasting lipids,glucose and insulin levels were measured. oral glucose tolerance test (ogtt) was performed in 75 of the obese patients. results: the frequency of w64r genotype was similar in obese and nonobese children. in obese children,relative body mass index,waist-to-hip ratio,serum lipid,glucose and insulin levels,as well as homeostasis model assessment of insulin resistance (homa-ir) scores were not different between arg allele carriers (w64r and r64r) and noncarriers (w64w). in 75 obese children,ogtt results showed that arg allele carriers had significantly higher 30-minute glucose levels (p=0.027). conclusion: w64r polymorphism of the β-3ar gene is not associated with obesity and waist-to-hip ratio in turkish children. although there were no relationships between the genotypes and lipid,glucose/insulin levels or homa-ir,the presence of w64r variant seemed to have an unfavorable influence on early glucose excursion after glucose loading. © journal of clinical research in pediatric endocrinology.