Gonadotropin-releasing hormone analogue treatment in females with moderately early puberty: No effect on final height

Objective: to investigate the effects of treatment with gonadotropin-releasing hormone analog (gnrha) on final height in girls who experienced moderately early puberty with symptoms beginning at 7-8.5 years of age. methods: female cases diagnosed with moderately early puberty which had started between ages 7 to 8.5 years were included in the study. in the treatment groups,all cases with a bone age ≤10.5 years constituted group 1 (n=18) and those with a bone age >10.5 years constituted group 2 (n=23). the 8 patients for which treatment approval could not be obtained constituted group 3. the 49 cases in all three groups were observed until they reached their final height. results: target height,target height standard deviation score (sds),final height,and final height sds values were similar in all 3 groups. final height showed a significant positive correlation with target height (p=0.000,r=0.54) and height at diagnosis (p=0.003,r=0.467) in all groups. linear regression analysis revealed that a 1 cm longer height at diagnosis increased the final height 0.213 fold,and a 1 cm longer target height at diagnosis increased the final height 0.459 fold. conclusion: we found that gnrha did not make a positive contribution to final height in cases of moderately early puberty. © journal of clinical research in pediatric endocrinology,published by galenos publishing.