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The growth characteristics of patients with Noonan syndrome: Results of three years of growth hormone treatment: A nationwide multicenter study
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نویسنده
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şıklar z. ,genens m. ,poyrazoğlu ş. ,baş f. ,darendeliler f. ,bundak r. ,aycan z. ,erdeve ş.s. ,çetinkaya s. ,güven a. ,abalı s. ,atay z. ,turan s. ,kara c. ,yılmaz g.c. ,akyürek n. ,abaci a. ,çelmeli g. ,sarı e. ,bolu s. ,korkmaz h.a. ,şimşek e. ,çatlı g. ,büyükinan m. ,çayir a. ,evliyaoğlu o. ,işgüven p. ,özgen t. ,hatipoğlu n. ,elhan a.h. ,berberoğlu m.
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منبع
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journal of clinical research in pediatric endocrinology - 2016 - دوره : 8 - شماره : 3 - صفحه:305 -312
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چکیده
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Objective: noonan syndrome (ns) is a multisystem disorder,and short stature is its most striking manifestation. optimal growth hormone (gh) treatment for ns is still controversial. in this study,using a nationwide registration system,we aimed to evaluate the growth characteristics and the clinical features of ns patients in turkey and their growth response to gh treatment. methods: children and adolescents with a diagnosis of ns were included inthe study. laboratory assessment including standard gh stimulation test results were evaluated. height increment of patients with or without gh treatment were analyzed after three years of therapy. © journal of clinical research in pediatric endocrinology.
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کلیدواژه
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Adolescents; Soluble endoglin; Subclinical atherosclerosis; Type 1 diabetes mellitus
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آدرس
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ankara university faculty of medicine,department of pediatric endocrinology,ankara, Turkey, istanbul university istanbul faculty of medicine,department of pediatric endocrinology,istanbul, Turkey, istanbul university istanbul faculty of medicine,department of pediatric endocrinology,istanbul, Turkey, istanbul university istanbul faculty of medicine,department of pediatric endocrinology,istanbul, Turkey, istanbul university istanbul faculty of medicine,department of pediatric endocrinology,istanbul, Turkey, istanbul university istanbul faculty of medicine,department of pediatric endocrinology,istanbul, Turkey, dr. sami ulus child health and disease training and research hospital,clinic of pediatric endocrinology,ankara, Turkey, dr. sami ulus child health and disease training and research hospital,clinic of pediatric endocrinology,ankara, Turkey, dr. sami ulus child health and disease training and research hospital,clinic of pediatric endocrinology,ankara, Turkey, göztepe training and research hospital,clinic of pediatric endocrinology,istanbul, Turkey, marmara university faculty of medicine,department of pediatric endocrinology,istanbul, Turkey, marmara university faculty of medicine,department of pediatric endocrinology,istanbul, Turkey, marmara university faculty of medicine,department of pediatric endocrinology,istanbul, Turkey, ondokuz mayıs university faculty of medicine,department of pediatric endocrinology,samsun, Turkey, ondokuz mayıs university faculty of medicine,department of pediatric endocrinology,samsun, Turkey, konya training and research hospital,clinic of pediatric endocrinology,konya, Turkey, dokuz eylül university faculty of medicine,department of pediatric endocrinology,izmir, Turkey, akdeniz university faculty of medicine,department of pediatric endocrinology,antalya, Turkey, gülhane military medical academy,department of pediatric endocrinology,ankara, Turkey, düzce university faculty of medicine,department of pediatric endocrinology,düzce, Turkey, dr. behçet uz children disease and surgery training and research hospital,clinic of pediatric endocrinology,izmir, Turkey, osmangazi university faculty of medicine,department of pediatric endocrinology,eskişehir, Turkey, tepecik training and research hospital,clinic of pediatric endocrinology,izmir, Turkey, konya training and research hospital,clinic of pediatric endocrinology,konya, Turkey, erzurum regional training and research hospital,clinic of pediatric endocrinology,erzurum, Turkey, istanbul university cerrahpaşa faculty of medicine,department of pediatric endocrinology,istanbul, Turkey, sakarya university faculty of medicine,department of pediatric endocrinology,sakarya, Turkey, bezmialem university faculty of medicine,department of pediatric endocrinology,istanbul, Turkey, erciyes university faculty of medicine,department of pediatric endocrinology,kayseri, Turkey, ankara university faculty of medicine,department of biostatistics,ankara, Turkey, ankara university faculty of medicine,department of pediatric endocrinology,ankara, Turkey
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Authors
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