Heart-type fatty acid binding protein level as a tool in identification of early cardiac effects of diabetic ketoacidosis

Objective: this study aimed to measure the serum levels of heart-type fatty acid binding protein (h-fabp) in patients presenting with diabetic ketoacidosis (dka) and diabetic ketosis (dk) and to determine its role in identifying early-period cardiac ischemia. methods: this prospective study included 35 patients diagnosed with dka,20 patients diagnosed with dk,and 20 control subjects. h-fabp,creatine kinase-mb (ck-mb),and troponin i levels were investigated at presentation in patients with dka and dk and in the control group. h-fabp values were measured again after acidosis correction in the dka patients. results: no statistically significant differences were found with respect to troponin i and ck-mb within the groups. the h-fabp values of dka patients at presentation were found to be significantly higher than those of dk patients and the control group (p=0.015). the h-fabp value of the dka group was also found to be significantly higher than the value at hour 36 after acidosis correction (p=0.0001). conclusion: we would like to propose h-fabp as a potential marker for indicating myocardial ischemia. © 2017 by turkish pediatric endocrinology and diabetes society.