Evaluation of the protective effect of N-acetylcysteine on contrast media nephropathy

Introduction: intravenous contrast agents can cause acute decline in kidney function, especially in patients with risk factors.objectives: in this study, we aimed to examine the ameliorative effect n-acetylcysteine (nac) to reduce the incidence of contrast nephropathy.patients and methods: this study was a prospective, randomized, double-blind clinical trial on 150 patients who underwent coronary angiography. the study was carried out on patients undergoing coronary angiography. patients were randomly assigned into 2 groups of intervention group and control subjects. intervention group took nac 600 mg orally twice a day. it was administered one day before angiography and continued until the second day after angiography. control subjects received saline only. serum creatinine was measured before and three days after coronary angiography.results: there was no significant difference between intervention and control groups at baseline (p > 0.05). however, there was a significant decline in creatinine level among nac patients (p = 0.001). saline group had significantly higher proportion of nephropathy cases than nac patientsconclusion: we found that the consumption of nac is useful for contrast induced nephropathy (cin) prevention.