Serum uric acid and diabetic nephropathy

Diabetic nephropathy is the most common cause of end-stage renal disease worldwide. recently, some prospective randomized controlled trials suggested that lowering of uric acid with allopurinol could decrease the severity of proteinuria and probably slow the progression of renal failure in diabetic patients. mechanism of beneficial effect of xanthine oxidase inhibitor may related to preventing uric acid-induced renal inflammation.