Can urinary neutrophil gelatinase-associated lipocalin have a role in the early diagnosis of acute kidney injury after coronary artery bypass graft?

Introduction: the role of urinary neutrophil gelatinase-associated lipocalin (ngal) as a prognostic biomarker in acute kidney injury (aki) associated with coronary bypass graft has been suggested in some studies. however, the results have been inconclusive in different studies.objectives: in the present research, we investigated the diagnostic and prognostic roles of ngal in iranian patients who developed aki after coronary bypass surgery.patients and methods: this study was cross-sectional conducted on adult patients undergoing coronary artery bypass graft (cabg) surgery. postoperative aki was defined based on the rifle (risk, injury, failure, loss and end-stage kidney disease) criteria. patients were divided into aki and non-aki groups. the urinary ngal and serum creatinine levels were measured at different times after surgery.results: out of 29 patients, men constituted 75.9% of cases. mean age of the patients was 61.4±7.7 years old and the mean duration of surgery was 4.9 ± 0.6 hours. based on serum creatinine, aki was diagnosed in 37.9%, 17.25%, and 13.8% of patients at first, second, and third day post-surgery, respectively. the urine ngal increased by 48.35% and 34.5% at 2 and 6 hours after surgery, respectively. however, there was no significant association between the urinary ngal level and the incidence of post-surgery aki.conclusion: this study showed that urinary ngal was inapplicable to independently diagnose or predict the outcome of transient aki associated with cabg.