Prevention of kidney injury after myocardial ischemia reperfusion is achievable with short-term protein restriction

Introduction: kidney injury is a serious complication after cardiovascular surgery. left ventricular dysfunction, pre-operative kidney dysfunction and inflammation can predict kidney injury after myocardial reperfusion.objectives: we aimed to study whether short-term protein restriction (pr) would influence blood urea nitrogen (bun) levels after myocardial reperfusion injury.materials and methods: male wistar rats fed with either ain-93m or ain-93m protein restricted diet one week before myocardial reperfusion injury. after surgery, feeding continued with ain-93m for 1 week.results: bun levels increased significantly compared to the pre-operative level in the control group (p = 0.03) and decreased significantly in the protein-restricted group (p = 0.01). multivariate analysis showed that pr through its effect on blood glucose (β = 1.2, 95% ci = 0.1-2.34), il-6 (β = -2.22, 95% ci = -3.9 – -0.54) and left ventricular ejection fraction (lvef) (β = -1.21, 95% ci = -2.34- 0.09) was able to protect the kidney from myocardial reperfusion.conclusion: short-term pr through modulating pre-operative il-6, post-operative blood glucose levels and lvef could prevent kidney injury after myocardial reperfusion injury.