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The importance of genetic study in steroid-resistant nephrotic syndrome
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نویسنده
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zununi vahed sepideh ,moghaddas sani hakimeh ,rajabzadeh sima ,nariman-saleh-fam ziba ,hejazian mina ,zununi vahed fatemeh ,hosseiniyan khatibi mahdi ,mohajel shoja mohammadali ,ardalan mohammadreza
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منبع
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journal of renal injury prevention - 2019 - دوره : 8 - شماره : 4 - صفحه:271 -282
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چکیده
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Steroid-resistant nephrotic syndrome (srns) is a challenging clinical task. it has heterogeneous etiology and extremely variable clinical outcomes and generally progresses to end-stage renal disease (esrd). different gene mutations in podocyte’s slit diaphragm, mitochondria, and cytoskeleton proteins, as well as glomerular basement membrane (gbm) have been associated with srns. these proteins regulate the function of the glomerular filtration barrier. advances in genetic approaches and podocytology have led to discover the srns-causing genes that lead to a better understanding of the drug resistance. more than 45 genetic mutations have been recognized in the hereditary form of srns. this review offers an update on the current knowledge of steroid resistance-causing gene mutations in podocytes. understanding the specific genes involved in srns would guarantee an optimum therapeutic benefit of steroid treatment.
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کلیدواژه
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Podocytopathy ,Proteinuria ,Gene mutation ,Podocyte
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آدرس
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tabriz university of medical sciences, kidney research center, Iran, tabriz university of medical sciences, kidney research center, Iran. university of sydney, school of life and environmental sciences, Australia, tabriz university of medical sciences, kidney research center, Iran, tabriz university of medical sciences, women’s reproductive health research center, Iran, tabriz university of medical sciences, kidney research center, Iran, tabriz university of medical sciences, kidney research center, iran, tabriz university of medical sciences, kidney research center, Iran, tabriz university of medical sciences, women’s reproductive health research center, Iran, tabriz university of medical sciences, kidney research center, Iran
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پست الکترونیکی
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ardalan34@yahoo.com
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Authors
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