APOL1 renal risk alleles in patients on chronic hemodialysis in Northwest of Iran

Introduction: apolipoprotein l1 (apol1) gene’s risk variants located on chromosome 22 are newly discovered factors for the development of chronic renal failure among african-american. these risk alleles were developed on the african continent as an evolutionary defense against sleep sickness due to trypanosoma brucei rhodesiense and then spread with human migrations.objectives: in the present study, we sought to examine these risk variants in a group of hemodialysis patients of northwest of iran.patients and methods: two hundred patients receiving hemodialysis in different centers of the city (tabriz in northwest of iran) were allocated randomly from a total number of 825 patients. the assessment of apol1 polymorphisms (rs73885319, rs60910145, and rs71785313) was conducted using polymerase chain reaction–restriction fragment length polymorphism (pcr-rflp) method. patients’ demographic data, history, and their biochemical parameters were recorded based on their last measurement.results: no proposed renal risk variants of apol1 gene in our hemodialysis population were found. all the participants had a wild genotype.conclusion: the results of our study match with reports from europe and asia. in the paleoanthropological point of view, our results do not support african human migration hypothesis.