The association of serum leptin with anthropometric indices, lipid metabolism and inflammatory biomarkers in patients with end-stage renal disease undergoing dialysis

Introduction: introduction: the close link between leptin and kidney function is nowconcerned that a significant increase in the level of bioactive form of leptin in progressivekidney injuries has been recently revealed.objectives: this study assessed the levels of leptin and its main determinants among endstagerenal disease (esrd) patients on hemodialysis or peritoneal dialysis.patients and methods: this cross-sectional study was performed on 78 patients sufferingfrom esrd that were planned for hemodialysis (68 patients) or peritoneal dialysis (10patients) three times a week. the baseline characteristics including demographics, medicalhistory, and medications were collected. the level of laboratory parameters including fastingblood sugar, lipid profile, urea, creatinine, calcium, phosphorus, and parathormone weredetermined using the special kits.results: the mean level of leptin was lower than 7.8 ng/ml in 35.9% of patients serum leptinof 8.7 to 13.1 ng/ml in 7.7% of cases and higher than 13.1 ng/ml in 56.4% of patients wasdetected. a direct association of plasma leptin with body weight, body mass index (bmi), andserum levels of triglyceride, total cholesterol, ldl-c, vldl and uric acid was seen. serumlevels of leptin were adversely associated with the duration of dialysis. in other patientswho underwent peritoneal dialysis, the serum levels of leptin were significantly related toleptin with body weight and bmi while adversely with the duration of dialysis. regardingassociation of inflammatory markers, this hormone was adversely associated with levels of β2microglobulin in the hemodialysis group but not in the peritoneal dialysis group. the level ofleptin was not associated with the concentrations of il6 and ifn-γ in both dialysis groups.conclusion: in esrd patients undergoing dialysis, the serum level of leptin is associated withlipid metabolism and bmi. these associations are expected more in the hemodialysis groupthan in the peritoneal dialysis group.