Hepcidin in hemodialysis patients and its association with anemia and serum iron indices

Introduction: anemia is one of the most common complications in dialysis patients. deficiencyof erythropoietin is the most common cause of anemia in dialysis patients. chronic kidneydisease (ckd) patients have a negative iron balance. hepcidin is an antibacterial peptidethat its synthesis is controlled by the iron surface and inflammatory markers and plays animportant role in iron hemostasis in hemodialysis patients. in the presence of anemia, thelevel of hepcidin in normal individuals is reduced. therefore, the normal level of hepcidin inckd individuals is considered high due to their anemia level, while, the level of hepcidin isreduced after dialysis.objectives: we aimed to study the level of hepcidin-25 in hemodialysis patients and itsrelationship with anemia and serum iron indices.patients and methods: in a cross-sectional study, 70 patients who fulfilled inclusion criteriaenrolled in the study. serum hepcidin 25 was measured by elisa method. at the same time,blood samples were taken to measure other indices including iron, ferritin, c-reactive protein(crp), total iron binding capacity (tibc) and albumin. hepcidin-25 levels compared withother mentioned parameters. statistical analysis was done in spss 18.0 software.results: no significant relationship between inflammatory cytokines, tibc and crpand erythrocyte sedimentation rate (esr) with hepcidin levels was detected. additionally,relationship between serum iron, ferritin and hepcidin levels was not significant (p > 0.05).conclusion: assessment of hepcidin 25 level for inflammation and iron status does not seemto be helpful for anemia management in hemodialysis patients.