Prevalence and antibiotic resistance pattern of extended spectrum beta lactamase producing Escherichia coli isolated from urinary tract infection

Introduction: urinary tract infection (uti) due to extended spectrum beta-lactamase(esbl)-producing bacteria including escherichia coli has become widespread. studies haveshown a trend toward higher mortality, longer hospitalization, greater hospital expenses andreduced rates of clinical and microbiologic response in esbl uti.objectives: the aim of this study is to determinate the prevalence and antibiotic resistancepattern of esbl producing e. coli isolated from uti.patients and methods: this cross-sectional study was conducted on 3126 samples. urinespecimens were cultured on eosin methylene blue (ebm) and blood agar. the disk diffusionstandard method (kirby bauer) was used to test the susceptibility of the drug on muller-hinton agar plates and results were reviewed based on clinical and laboratory standardsinstitute (clsi) criteria. the reviewing of esbl-producing uropathogens was carriedout using combined disk test (cdt) by using cefotaxime (ctx; 30 μg) and cefotaximeclavulanicacid (ctx; 30 μg /ca:10 μg) disks and clsi protocol.results: out of 291 e. coli isolates, 108 (37.11%) are esbl-producer and 183 (62.89%) arenon–esbl-producer. among esbl-producing e. coli, the highest antibiotic resistance wasobserved with cefotaxime (100%), amoxicillin (97.22%) and piperacillin (96.3%) and thehighest antibiotic sensitivity was observed with meropenem (93.5%), nitrofurantoin (81.48%)and gentamicin (55.56%).conclusion: we recommended that cephalosporins, penicillins and cotrimoxazole are notsuggested in the treatment of esbl-producing e. coli. on the other hand, carbapenems as afirst line and aminoglycosides as the next step in the treatment of esbl-producing e. coli arerecommended.