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Metformin; a mini-review to its antioxidative and anti-inflammatory properties
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نویسنده
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abbaszadeh abolfazl ,koushki sahar ,koushki shirin ,eskandarzadeh marzieh ,hasanvand amin
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منبع
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journal of renal injury prevention - 2018 - دوره : 7 - شماره : 1 - صفحه:7 -10
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چکیده
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Metformin, a hypoglycemic drug, increases peripheral glucose uptake, decreases liver glucoseproduction and suppresses insulin resistance in liver and skeletal muscle. the molecularanti-inflammatory mechanism of metformin involves the reduction of the level of proinflammatory cytokines through ampk activation. it can reduce endothelial dysfunction by ameliorating the expression of inflammatory gene and protein like vascular cell adhesion molecule-1 (vcam-1), and vasodilating maternal vessels. many studies showed that ampk activation were the main contributors to the antioxidant and anti-inflammatory effects of metformin.
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کلیدواژه
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Metformin ,Antioxidative ,Anti-inflammatory
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آدرس
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lorestan university of medical sciences, department of surgery, Iran, lorestan university of medical sciences, student research committee, Iran, lorestan university of medical sciences, student research committee, Iran, lorestan university of medical sciences, student research committee, Iran, lorestan university of medical sciences, faculty of pharmacy, department of pharmacology and toxicology, Iran
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پست الکترونیکی
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dr.hasanvand@yahoo.com
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Authors
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