Epithelial and endothelial mesenchymal transition and their role in diabetic kidney disease

Diabetic nephropathy (dn) is the main cause of end-stage renal disease. on the other hand,there are a couple of evidences, including human studies, which prove the role of epithelialmesenchymal transition (emt) in pathophysiology of dn. emt is characterized by loss ofepithelial proteins and gain of mesenchymal markers. emt is induced via three main conduit;tgfβ/smad, integrin /ilk as well as wnt/β-catenin pathways. besides, numerous studiesillustrated how drugs and agents can modify this phenomenon. on the other hand, endothelialmesenchymal transition (endomt) has a well-known role in pathophysiology of diabeticnephropathy which has been studied in animal and human. here, several drugs and modifierswhich have been studied to ffigure out if they can amend nature of emt or endomt arereported briefly