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An update on allopurinol and kidney failure; new trend for an old drug
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نویسنده
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alirezaei amirhesam ,argani hassan ,asgharpour masoumeh ,bahadorimonfared ayad ,bakhtiyari mahmood
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منبع
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journal of renal injury prevention - 2017 - دوره : 6 - شماره : 4 - صفحه:297 -302
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چکیده
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Allopurinol is an inhibitor of xanthine oxidase (xo) enzyme. this drug is a reducer of uric acid in the body and one of the golden drugs with worldwide administration. xo is an important biological source of free radical generation. allopurinol as an antioxidant, has direct and indirect antioxidant activity on these free radicals such as hydroxyl radical and superoxide anion. the purpose of this paper is to determine the impact of allopurinol on some aspects of renal disturbances such as renal ischemia/reperfusion injury (iri), nephrotoxicity and contrast-induced nephropathy (cin).
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کلیدواژه
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Allopurinol ,Free radicals ,Hyperuricemia ,Renal ischemia ,Nephrotoxicity ,Contrast-induced nephropathyinjury
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آدرس
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shahid beheshti university of medical sciences, clinical research and development center, shahid modarres hospital, department of nephrology, ایران, shahid beheshti university of medical sciences, clinical research and development center, shahid modarres hospital, department of nephrology, ایران, rouhani hospital of medical sciences, department of nephrology, ایران, shahid beheshti university of medical sciences, faculty of medicine, department of health & community medicine, ایران, alborz university of medical sciences, school of medicine, department of community medicine, ایران. tehran university of medical sciences, school of public health, department of epidemiology and biostatistics, ایران
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Authors
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