Comparing the efficacy of desmopressin and oxybutynin combination therapy and desmopressin monotherapy in children with primary nocturnal enuresis; a randomized clinical trial

Introduction: nocturnal enuresis is known as the most common developmental problems of childhood which has often a familial basis. it is usually benign and gradually disappears with age.objectives: this study was conducted on children with primary nocturnal enuresis to compare the efficacy of desmopressin and oxybutynin combination therapy with desmopressin monotherapy.patients and methods: this clinical trial was conducted on 59 patients (age range; 5 to 15 years) with primary nocturnal enuresis who had referred to our center in tabriz in 2012. the participants were divided into two groups as group 1 (30 participants) and group 2 (29 subjects). for three months, one group received desmopressin and oxybutynin and the other group received desmopressin alone. descriptive statistics (mean ± sd and frequency) and chi-square test was conducted.results: in the group treated only with desmopressin, 72.4% of the participants were completely cured in 1 month and 44.8% in 3 months. in the group treated with combination of desmopressin and oxybutynin, 83.34% were cured in 1 month and 86.7% in 3 months.conclusion: desmopressin and oxybutynin combination therapy is more effective than desmopressin monotherapy for treating children with enuresis.