Association between vitamin D, parathyroid hormone and inflammatory markers in urolithiasis patients

Introduction: hypercalciuria plays an important role in the pathogenesis of renal calculi. the role of vitamin d, parathyroid hormone (pth), inflammatory markers highly sensitive c-reactive protein (hs-crp) and interleukin-6 (il-6) in the development of renal calculi has not well defined. objectives: to assess the serum levels of vitamin d, pth, hs-crp and il-6, urinary and serum calcium and phosphorus levels in patients with renal calculi and to compare these parameters with healthy controls patients and methods: it was a cross-sectional study. about 41 confirmed renal calculi patients and 41 age and sex matched controls were recruited. patients with malignancies, hyperparathyroidism, chronic disease, and patients taking vitamin d supplementations were excluded. serum levels of 25(oh) vitamin d, i-pth, hs-crp, il-6, calcium and phosphorous, 24 hours urine levels of calcium and phosphorus were estimated results: there was a statistical significant difference in the serum levels of 25(oh) vitamin d (12.26 vs 19.61 ng/ml), i-pth (75.5 vs. 33.5 pg/ml), hscrp (5117.05 vs. 1721.87 ng/ml), il-6 (13.49 vs. 1.47 pg/ml) calcium (11.5 vs. 9.4 mg/dl) and urinary calcium (370.5 vs. 342 mg/d) and phosphorous levels (1172 vs. 1432 mg/d) between the cases and the control. there was negative correlation between the levels of i-pth and vitamin d (r = - 0.765) and positive correlation between i-pth and hscrp, il-6, serum calcium and urine calcium (r = 0.353, 0.340, 0.522, 0.501 respectively) conclusion: there was vitamin d inadequacy and increased levels of pth, il-6 and c-reactive protein, calcium in patients with renal calculi when compared with healthy controls.