evaluation of ppp2r5c gene expression in iranian patients with b-acute lymphoblastic leukemia and its association with clinical and laboratory findings

Introduction: ppp2r5c is one of the regulatory b subunits of protein phosphatase 2a (pp2a), which is a tumor suppressor. ppp2r5c plays a critical role in cell proliferation, differentiation, and transformation. considering these vital functions, we investigate the gene expression in iranian patients with b-acute lymphoblastic leukemia (b-all) and its association with clinical and laboratory finding. materials and methods: in this case-control study, peripheral blood samples were collected from 60 b-all patients and 30 healthy controls. ppp2r5c expression levels were determined by real-time pcr. after calculation of ct for target and control genes, we calculated δct. finally we compared the ppp2r5c expression levels in patients with control group. results: significantly higher expression of ppp2r5c was found in the b-all patients (2.15±2. 50) compared with control group. there was no correlation between ppp2r5c expression and clinical and laboratory findings and fab (french-american-british) subtype of patients. conclusion: we demonstrated ppp2r5c overexpression in b-all patients. although there was no significant correlation between ppp2r5c expression, clinical and laboratory finding and also with fab subtypes of patients.