effects of flaxseed oil supplementation on renal dysfunction due to ischemia/reperfusion in rat

Introduction: this study was designed to evaluate the effects of treatment with flaxseed oil (fso) on renal ischemiareperfusion (rir) injuries in rats.materials and methods: in this study, 32 wistar rats were randomly studied in four groups: co+ns (control group with normal saline administration), sh+ns (sham group with normal saline administration), rir+ns and rir+fso. fso (0.2 ml) was administered orally (gavage) for 14 days (~ 800 mg/kg body weight).&nbsp; blood samples were collected for the detection of blood urea nitrogen (bun) and creatinine levels.&nbsp; malondialdehyde (mda) and superoxide dismutase (sod) levels were evaluated in the renal tissue. tubular damages were examined using histopathological studies.results: significantly elevated mda (p<0.05) and depressed sod levels (p<0.05) comparison between rir+ns group and control+ns and sh+ns groups revealed in the condition of rir. treatment with fso, however, significantly lowered the mda (p<0.05) and enhanced sod levels (p<0.05) after rir injury. histopathological results confirmed the biochemical studies and tubular necrosis score was reduced in the rir+fso group.conclusion: this study therefore suggests that the aqueous flaxseed oil may be useful agents for the prevention of renal ischemiareperfusion (rir)induced oxidative injury in rats.