the effect of 12 weeks of intermittent resistance training with algomed supplementation on plasma levels of fetuin a and fetuin b in men with obesity

Introduction: fetuin a and b are hepatokines linked to obesity and metabolic disorders. the present study aimed to investigate the effect of 12 weeks of intermittent resistance training combined with algomed (chlorella vulgaris) supplementation on plasma levels of fetuin a and b in obese men. materials & methods: this quasi-experimental study included 44 obese men (bmi > 30), aged 23–32 years, randomly assigned to four groups (n = 11 each): control, resistance training, algomed supplementation, and resistance training + algomed. the training protocol was performed three times per week for 12 weeks. the supplement groups received 1800 mg/day of algomed. plasma levels of fetuin a and b were measured by elisa before and after the intervention. baseline differences were assessed using one-way anova. within-group changes were analyzed using paired t-tests, and between-group comparisons of post-test values were conducted using ancova with initial values as covariates. bonferroni post hoc tests were applied where appropriate (p < 0.05).results:  ancova results showed significant differences in post-test levels of both fetuin a and fetuin b between the groups (p < 0.0001). post hoc analysis indicated that the training + algomed group had significantly lower fetuin-a levels compared to the control group. furthermore, fetuin-b levels were significantly reduced in all intervention groups compared to the control, with the greatest reduction observed in the training + algomed group compared to all other groups (p < 0.0001).conclusion:  twelve weeks of intermittent resistance training combined with algomed supplementation had a synergistic effect in reducing plasma levels of fetuin a and b in obese men. these findings suggest potential metabolic benefits for this combined intervention strategy.