The Impact of Capecitabine and Combined Training on BRCA1 Gene Expression in Breast Cancer Induction

Introduction: this study explores the combined effects of concurrent training and capecitabine consumption on breast cancer prevention and therapy, focusing on the modulation of brca1 gene expression. material & methods: in the main study, 12 mice were divided into groups, including exercise-tumor-exercise (ete), exercise-tumor-exercise+drug (ete + d), and various others. resistance and endurance training were conducted five days a week for 12 weeks before and eight weeks after tumor induction, accompanied by capecitabine administration. brca1 gene expression was assessed post-intervention using spss 20. results: mc4-l2 injection induced tumors. both pre and post-cancer induction, exercise significantly increased brca1 gene expression (p = 0.001, p = 0.001). exercise combined with post-cancer capecitabine led to increased brca1 expression (p = 0.001). capecitabine alone post-cancer also elevated brca1 expression (p = 0.001). exercise, exercise with capecitabine, and capecitabine alone post-cancer showed significantly higher brca1 expression than exercise pre-cancer (p = 0.001). exercise-tumor-exercise and exercise-tumor- exercise+drug groups exhibited increased brca1 expression compared to exercise-tumor-drug (p = 0.001). conclusion: the ete+d protocol, involving exercise and capecitabine postcancer, increased brca1 expression, suggesting potential roles in tumor prevention and therapy.